Sleep Enhancement by Saffron Extract in Randomized control trial
Akemi Nishide1, Yukihiro Shoyama2, Tuneyuki Yamamoto2, Takashi Fujita2, Keiko Ohnuki1, Tomonari Watanabe3, Yoshiteru Nagaregawa3, Kuniyoshi Shimizu4 and Koichiro Ohnuki5
1: User Life Science Co.Ltd., Niho, Izuka, Fukuoka 820-0115, Japan
2: Faculty of Pharmaceutical Science, Nagasaki International University, Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan
3: SBS Co. Ltd., Tenjin, Chuo-ku, Fukuoka 810-0001, Japan
4: Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
5: Department of Biological and Environmental Chemistry, Kinki University Kyushu, Kayanomori, Izuka, Fukuoka 820-8555, Japan
Address correspondence to: Koichiro Ohnuki, Department of Biological and Environmental Chemistry, Kinki University Kyushu, Kayanomori, Izuka, Fukuoka 820-8555, Japan
Tel: +81- 50-5583-9758, Fax: +81+20-4665-3490
Back ground. We conducted the clinical trial using 21 healthy adults randomly allocated into the saffron extract group or the placebo group in order to confirm the increase of sleeping quality by taking saffron extract. The aim of this study is to determine the effect of saffron extract on sleeping quality in 21 healthy adults.
Trial design. A clinical parallel, double-blind, randomized control trials (RCT) was conducted. Subgroups were defined by good sleeper or poor sleeper using PSQI test were analyzed.
Method. The participants, self-reporting information were under randomized controlled trial (RCT) study designed for all participants receiving the saffron extract (crocin: 0.6mg/day), or placebo.
Result. There was a significant reduction of score for the Pittsburgh sleep quality index (PSQI) only in the group treated with the saffron extract. In addition, a significant saffron extract effect on daytime dysfunction over 4 weeks was apparent between extract group and placebo group in the subjects with poor sleeper at baseline.
Conclusion. Overall, we observed the effect of saffron extract on sleeping quality in healthy adults. This result was discussed with the previous studies that saffron and Japanese Kampo medicine prescription containing saffron extract enhanced sleep, and crocin in saffron induced REM and non-REM sleeping.
Key word: Crocus sativus, saffron, quality of sleeping, Pittsburgh sleep quality index, clinical trial
Akemi Nishide (User Life Science Co. Ltd., Japan)